The Enabling Absorption Device (ENA) is a new in vitro tool that captures the
complex dynamics between digestion and absorption in the gastro-intestinal tract.
The ENA monitors digestion, dissolution/release and permeation in the same assay,
enabling a more physiologically relevant evaluation of the absorption of API´s, drug
loaded formulations, and excipients in vitro
The ENA provides a dynamic representation of conditions in the small intestine. It
provides ”sink conditions” for adequate absorption assessment, and it captures
potential membrane-mediated excipient effects.
The ENA tests the complete dosage form, it enables comparison beween different formulation principles, and it can be used with difficult drug classes (BCS class II).
Oral administration is the most convenient and least invasive route of drug administration. Most API candidates have low solubility, translating into low bioavailability when delivered orally. Enabling formulations increase their solubility, but current in vitro methods fail to predict the best dosage form for optimal in vivo performance. Enphasys has developed, patented and validated the Enabling Absorption Device, a smart benchtop assay that mimics digestion and absorption and provides superior in vitro in vivo correlation (IVIVC).
The vast majority of animals used in drug development are consumed in
formulation testing. The ENA will significantly reduce these numbers
Finding the optimal formulation of a drug candidate using standard methods is
laborious and time consuming. A comprehensive analysis with the
ENA takes just a few weeks
The ENA is validated in several species and demonstrates superior IVIVIC to
standard methods. It correctly picks the top performing formulation amongst
The ENA correctly identifies the best performing formulation candidate regardless of type and provides detailed mechanistic information on formulation performance for further optimization. An optimal formulation
increases chances of successful clinical trials, the most expensive part of drug development